Which substance converts fibrinogen to fibrin during coagulation?

Prepare for the Anatomy and Physiology II Milestone 1 Test with engaging questions, in-depth explanations, and focused study resources. Start your journey to excel in your exam!

Multiple Choice

Which substance converts fibrinogen to fibrin during coagulation?

Thrombin is the enzyme that converts fibrinogen into fibrin, forming the mesh that stabilizes a clot. In the coagulation cascade, thrombin is generated from its inactive precursor, prothrombin, by the prothrombinase complex. Once active, thrombin cleaves fibrinogen to produce fibrin monomers, which polymerize to form the insoluble fibrin network. It also activates factor XIII, which cross-links the fibrin strands and strengthens the clot. Other options don’t fit because plasmin breaks down fibrin (fibrinolysis), fibrinogen is the substrate, and prothrombin is just the precursor to thrombin.

Thrombin is the enzyme that converts fibrinogen into fibrin, forming the mesh that stabilizes a clot. In the coagulation cascade, thrombin is generated from its inactive precursor, prothrombin, by the prothrombinase complex. Once active, thrombin cleaves fibrinogen to produce fibrin monomers, which polymerize to form the insoluble fibrin network. It also activates factor XIII, which cross-links the fibrin strands and strengthens the clot. Other options don’t fit because plasmin breaks down fibrin (fibrinolysis), fibrinogen is the substrate, and prothrombin is just the precursor to thrombin.

More practice questions