Which cellular element is primarily responsible for hemostasis by forming a temporary plug?

• A. Erythrocytes
• B. Lymphocytes
• C. Basophils
• D. Platelets

Answer: (D)

Platelets are the cellular element responsible for creating a temporary hemostatic plug. When a vessel is injured, platelets rapidly adhere to exposed collagen through von Willebrand factor, become activated, and release granules containing ADP and thromboxane A2 to recruit and activate more platelets. This aggregation forms a quick, temporary platelet plug that seals small breaches while the coagulation cascade strengthens the clot with fibrin. Erythrocytes don’t initiate a plug, lymphocytes are immune cells, and basophils mainly release mediators that influence inflammation and anticoagulation rather than forming the platelet plug.