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Multiple Choice

Where does the extrinsic coagulation pathway converge?

The extrinsic pathway converges with the intrinsic pathway at the common pathway. The tissue factor–VIIa complex of the extrinsic route activates Factor X, and the intrinsic route also ends by activating Factor X. Once Factor X is activated, the process moves into the common pathway, where Factor X (with Factor V) forms the prothrombinase complex to convert prothrombin into thrombin, and thrombin then converts fibrinogen to fibrin to form the clot. Platelet aggregation and fibrinolysis are involved in other aspects of hemostasis, but the point where the two pathways meet is the common pathway.

The extrinsic pathway converges with the intrinsic pathway at the common pathway. The tissue factor–VIIa complex of the extrinsic route activates Factor X, and the intrinsic route also ends by activating Factor X. Once Factor X is activated, the process moves into the common pathway, where Factor X (with Factor V) forms the prothrombinase complex to convert prothrombin into thrombin, and thrombin then converts fibrinogen to fibrin to form the clot. Platelet aggregation and fibrinolysis are involved in other aspects of hemostasis, but the point where the two pathways meet is the common pathway.